To see a list of supported conditions, please log in to your MyHeritage account and select the DNA kit you wish to upgrade. You can view the full list here: https://www.myheritage.com/health/disease-list
Alternatively, you can find a list below. Click on the arrow next to the list you would like to view in order to open the collapsible section.
1. Polygenic Risk Scores (PRS)
1. Polygenic Risk Scores (PRS)
These reports estimate your relative risk for common conditions influenced by many genetic variants.
Cardiovascular: Atrial fibrillation, Heart disease, and High blood pressure.
Cancer: Female breast cancer (Female only), Colorectal cancer, Prostate cancer (Male only), and Thyroid cancer.
Metabolic & Other: Type 2 diabetes, Chronic kidney disease, Glaucoma, and Obesity and High BMI.
2. Monogenic Risk Reports
2. Monogenic Risk Reports
These reports identify specific variants in individual genes that are known to significantly increase the risk of developing a condition.
Hereditary Cancers:
Hereditary BRCA cancers: 103 variants across the BRCA1 and BRCA2 genes.
PALB2-associated breast cancer: 11 variants in the PALB2 gene (e.g., Gln60Argfs, Met723Valfs*21, Tyr1183Ter).
Neurological:
Late-onset Alzheimer's disease: APOE variants Cys112Arg and Arg158Cys.
Late-onset Parkinson's disease: GBA (Asn370Ser) and LRRK2 (Gly2019Ser).
Metabolic & Digestive:
Celiac disease: HLA-DQA1 (HLA-DQ2) and HLA-DQB1 (HLA-DQ8).
Crohn's disease: NOD2 variants Leu1007Profs and G908R.
Hereditary fructose intolerance: 4 variants in the ALDOB gene (A175D, A150P, Asn120Lysfs, N335K).
Alpha-1 antitrypsin deficiency: SERPINA1 variants GLU342LYS and GLU264VAL.
G6PD deficiency: G6PD variants VAL68MET and SER218PHE.
Other Risks:
Age-related macular degeneration: ARMS2 (A69S) and CFH (Y402H).
Hereditary hemochromatosis: HFE variants C282Y and H63D.
Hereditary thrombophilia: 4 variants across F2 (20210G>A), F5 (R506Q), PROC (ARG189TRP), and PROS1 (S460P).
Sickle cell anemia: HBB variant Glu6Val.
Limb-girdle muscular dystrophy (type 2D): SGCA variant R77C.
Nonsyndromic hearing loss (connexin 26): 4 GJB2 variants (Met34Thr, 167delT, 35delG, Leu79Cysfs).
Niemann-Pick disease (types A and B): 4 SMPD1 variants (fsP330, LEU302PRO, ARG608DEL, R191L).
PMM2-congenital disorder of glycosylation: 4 PMM2 variants (F119L, P113L, R141H, V231M).
Joubert syndrome 2: TMEM216 variant R12L.
Mucolipidosis type IV (ML4): MCOLN1 variant IVS3AS-2A>G.
Rhizomelic chondrodysplasia punctata (type 1): PEX7 variant L292X.
Usher syndrome (type 2A): USH2A variant 2299del.
3. Carrier Status Reports
3. Carrier Status Reports
These reports determine if you carry a genetic variant that could be passed to your children for various hereditary conditions.
Cystic fibrosis: 20 variants in the CFTR gene (e.g., PHE508DEL, GLY542TER, GLY551ASP).
Tay-Sachs disease: 7 variants in the HEXA gene (e.g., c.1274_1277dup, IVS12+1G>C, Gly269Ser).
Ataxia-telangiectasia syndrome: ATM variants R35X and R447X.
Familial dysautonomia: IKBKAP variant IVS20+6T>C.
Fanconi anemia: 4 FANCC variants (R548X, Leu554Pro, IVS4+4A>T, 322delG).
Gaucher disease: GBA variants Asn370Ser and Val394Leu.
Galactosaemia: 5 GALT variants (T138M, K285N, Q188R, L195P, S135L/S135W).
Dermatosparaxis Ehlers-Danlos syndrome (dEDS): ADAMTS2 variant Q225X.
GRACILE syndrome: BCS1L variant S78G.
Please note:
If you didn't find a condition you were looking for, it could still be added over time. We are continuously working on improving and expanding our features. When purchasing the MyHeritage Health subscription, you receive unlimited access to even more Genetic Risk and Carrier Status Reports that will be made available to you over time.
You can learn more about the MyHeritage Health subscription in the following article: What is the MyHeritage Health subscription?